Researchers from Barcelona's Autonomous University (UAB, Spain) and Maryland Baltimore County (UMBC, USA) have discovered a new process that can establish long-lasting synthetic antibacterial drug resistance, even of their own. Clinical use.
Synthetic antibacterial drugs, such as sulphonamide, are made from chemistry designs that are entirely designed in the laboratory, while antibiotics are based on those made by microorganisms such as viruses, fungi, yeasts or bacteria.
Sulfonamide was the first synthetic antibacterial to enter into a clinical setting in & # 39; A first half of the last century was introduced and is now used in & # 39; A first line of clinical intervention, along with other medicines, especially in developing countries, although it is also widely used as a precautionary treatment in agriculture.
Researchers have been able to analyze the large bactaric genome capability of identifying the origin of mobile genetic elements that carry the sulfonamide resistance that is often found in superbugs in hospitals.
By comparing seismic and phylogenetic analysis analysis, they can conclude that the resistance against sulphamide appears in two families of soil bacteria (Rhodobiaceae and Leptospiraceae) over 600 million years ago, from a mutation in the target of this drug
According to the researchers, the identified genes were transferred to other bacteria from the massive use of sulfonamide in agriculture and hospitals, in the middle of & # 39; e 20th century.
"The findings confirm the need to use multiple combination therapies that set different mechanisms of resistance in the hospital, to another side, and the origin of" # ~ "; resistance genes have been found in bacteria that live and live in soil, It warns us of the need to reduce the current use of antibacterials in agriculture, "said Ivan Erill .
"We hypothesized that the great genetic variability of backbone has promoted the mutation of the resistance genes that we identified," "without the need for the selective pressure of sulfoamide or a like-like-like substance in & "Nature", stated Jordi Barbé, leader of a research published in "Frontiers in Microbiology" magazine.