Friday , April 23 2021

They find a new process of resistance to drugs in the back



A team of researchers has discovered a new process that can take long-term clinical use for synthetic-type antibacterial drugs in bacterial populations.

The research was led by Jordi Barbé, researcher of the Molecular Microbiology Group of & # 39; a University of Barcelona (UAB) (Catalunya, Spain) and Ivan Erill, of & # 39; biological biology; a University of Maryland Baltimore County (UMBC) and published in Frontiers in microbiology.

Researchers have been able to analyze the large bactaric genome capability of identifying the origin of mobile genetic elements that carry the sulfonamide resistance that is often found in superbugs in hospitals.

Through the comparative analysis of phylogenetic diseases and techniques, they can conclude that the sulfamide inhibitors appeared in two families of basic bacteria (Rhodobiaceae and Leptospiraceae) over 600 million years ago, from a mutation in the target of these drugs. The identified genes were quickly mobilized and transferred to other bacteria, from a massive use of sulfonamide in agriculture and in & # 39; a clinic, in & # 39; the middle of & # 39; e 20th century.

The description of a process of preventing anti-bacterial drugs for its invention and in the absence of natural analogues involving the appearance of resistance genes has significant expenditure on the development and practice of future drugs, according to researchers.

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The team of researchers made the study. From left to right: Ivan Erill, Pilar Cortés, Jordi Barbé and Miquel Sánchez-Osuna. (Photo: UAB)

"The findings confirm the need to use a multi-drug combination therapy, which sets several mechanisms of resistance in the hospital, on another side, or found the origin of resistance genes is in barks that live in and in aquifers, warns us of the need to reduce the current use of antibacterials in agriculture, "says Erill.

"Our hypothesis is that the great genetic variable of the backbones favored the mutation of the resistance genes that we identified, without the need for the selective pressure of sulfonamide or a similar substance in & # 39; the nature, "says Jordi Barbé. "In this sense, the study draws on the fact that the terrifying baking pancake attacks the rapid selection and mobilization of existing ones before the introduction of a new synthesized drug".

Synthetic antibacterial drugs such as sulfamide are made from those designed entirely in the laboratory, while antibiotics are based on those made by microorganisms such as viruses, fungi, animals or bacteria.

In nature, antibiotic resistance genes can be found before they are clinically applicable, to generate the same microorganisms against the antibacterial substances of their competitors. However, this phenomenon is not expected to occur with synthetic drugs. And in no case has a process such as that found in this study identified a mutation in & # 39; the audience of & # 39; drugs, say the researchers.

Sulfonamide was the first synthetic antibacterial in the clinical setting in & # 39; a first half of the previous century. It is currently used in the first line of clinical intervention, along with other drugs, especially in developing countries. It is also widely used as a prevalent treatment in agriculture. (Source: UAB)


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