Friday , July 23 2021

Study that & # 39; s for answers to & quot; sickness & quot; – Uppsala



– Although we know a lot more today & # 39; for a few years about how & # 39; t expresses CLS itself and what in & # 39; the sleep period in & # 39; the brain is born, the cause of the disease is still completely unknown, says neurologist Anne-Marie Landtblom, professor of neurology at the University of Uppsala and Guest professor at the University of Linköping.

She has been researching more than 30 years of research into the environment of KLS and it is largely her for the Academic Hospital and the University School in Linköping that young people with sibling KLS are normally called pediatric and pediatric psychiatric clinics in both Sweden as our northern neighbor. At present, she has about 50 KLS patients, which is also a very large number for such rare diseases also internationally.

That the cause of KLS is still unknown is not to say that there is no less hypothesis about what can lie, contrary to the opposite.

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Anne-Marie Landtblom

One hypothesis is that KLS – like multiple sclerosis or rheumatoid arthritis – is an autoimmune disease, thus a disease in which the immune system is diverted and attacking its own body.

Another is that there is discrimination in a hormone system, the hypocretin / orexin system, which is important for both sleep, appetite and blood serum levels.

A third hypothesis is that, in the sleep period, the patient may be asleep, but that sleep is so effective that the body still reacts as if it were experimenting with a bad sleep.

– All of this hypothesis we can investigate by the presence of various antigens, hormones and other proteins in spinal cord and blood problems. The samples are free of symptoms both in sleep and in patients. They are stored in a new towed biobank to allow for complete new future analyzes, "says Anne-Marie Landtblom.

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Anne-Marie Landtblom

The researchers hope that the study will provide important new knowledge about the pathological mechanisms at KLS, which can be added to new types of medication and other treatments of the disease.

– At present, the study also provides knowledge about generalized slimming mechanisms, which can also be useful in the development of treatments for other and more common sleep disorders than KLS, says Anne-Marie Landtblom.


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