Singapore researchers have developed a contact lens patch-type system to give medicines to the eye to combat different conditions.
Nanyang Technological University, Singapore (NTU Singapore) scientists developed a & # 39; contact lens & # 39; patch with micronutils that have a painful and efficient alternative to current methods of treatment of eye diseases such as glaucoma and macular degeneration.
Current local therapeutic methods such as scratches and salvage are driven by the natural defenses, flashing and tearing. Eye injections can be painful and carry risk for infection and eyes damage. As a result, some patients are not in a position to keep up with the press chain regime for their eagle weapons, many of which require long-term management.
The motion-conscious-patch, to test successfully in mice, is covered by biologically different micronedelies that provide drugs in the eyes in a controlled release. After pressing on the braces briefly and gentle – full of love or contact lenses – release the drug-hormone microns through self and stay in & nbsp; The cornea, the removal of the medicine in time when it is unlocked.
At tests on coronary fiscal measurements, a single application of the 90-point patch was more effective in denying the conditions when applying for a single requirement with 10 times more drug content.
This novel approach was developed by a team led by NTU Singapore Professor Chen Peng of School of Chemical and Biomedical Engineering (SCBE), with clinical intelligence of the Singapore National Eye Center Associate Professor Gemmy Cheung.
The team included assistant professor Wang Xiaomeng from NTU's Lee Kong Chian School of Medicine, assistant professor Xu Chenjie, and research assistant Dr. Aung Than of SCBE.
Prof. Chen, the biotechnology expert behind the microwave patch, said that this approach could be the non-medical need for a local, long-lasting and efficient eye-medical care with a good behavior of patients.
He said, "The microneedles are made of a substance that is naturally found in the body, and we have shown in laboratory tests on mosses that are without pain and minimal invasive. If we repair successfully with the same problems In human trials, the patch can be a good option for eyeglasses that are long-haired at home, such as glaucoma and diabetic retinopathy.
"Patients who find it difficult to keep up with the regulation of repeating octopus and salivia would also find the patch useful to make the potential of the same therapeutic effect with a smaller and less frequent dosage . "
Prof. Chen Fooe added that the patch could also help to get the standing sickness control of eyes in the body. A 2018 study program is projected that patients with eye diseases in Singapore grow strongly until 2040, with glaucoma, diabetes retinopathy and age-related macular disorders that duplicate.
Spatial approach to treatment of eye diseases
At present, local treatments are included through the physiological and structural barrier of eyes, including blinking and tearing that every drug is applied to & quot; The surface of the eye is present.
Topic medicines such as endocrine and salts earn repetitive applications with high doses or less than 5 percent of drug samples are taken up by the eye, and the medicine is quickly stretched out by the eye.
Converting injections can impress the overlying, but the same problem impedes or a bad drug retreat through the backflow of injected resolving and subsequent tear wash. Apart from the consequence of a risk of infection or permanent respiratory illness, patient patients are poor due to lack of pain and need for frequent client visits.
Prof. Chen adds: "These two current methods only make a burst of drug with a short effective duration. This is not ideal, especially when treatment of chronic progressive imaging that requires longer and lasting treatment, such as glaucoma."
To reduce these problems, the team developed a 2mm 2mm patch with nine microneeds that can be loaded with medicines for laboratory tests on mice.
Each needle, denser or a beach of herd is shaped as a pyramid for optimal tissue penetration. The needle is made of hyaluronic acid, a substance that is found in the eyes and is often used in octopus. A modified version of hyaluronic acid is added to a second layer of # forming a needle to slip the rate where the needle disappears, ensures a worse release of drugs.
Dr. Than, NTU research promotion at SCBE, plants and experiments over a week on mildew malignant mildew, a visible threat in which new blood vessels grow in corneal effusion due to oxygen overflow. In this study, researchers learned the microneedles with DC101, an anticorrosion that boosts the growth factor that boosts blood transfusion.
In Mexico with the patch, there was a 90 percent reduction in the area of blood vessels with a single treatment dose of 1 microgram. However, in contrast, when a single drop of the same drug with a much higher dosage of 10 micrograms was applied, there was no significant reduction.
There was also no puncture found on a cornea after a week, suggesting that the microseeds are strong enough to drank the grain, but not too much to spare the entire cornea.
Prof Chen said the team has recorded a patent and currently works on further improvement of the patch technology. They also look for partner clients scientists to investigate the feasibility of medical tremors.
The study was published in Nature Communications.