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Cardiovascular Disease, Genetically Linked Alzheimer's Disease – Washington University School of Medicine, St. Louis


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Cholesterol, and triglycerides can reduce the risk of Alzheimer's, research shows.

Michael Worful's illustration

DNA research from more than 1.5 million people has identified DNA points that increase and increase the risk of cardiovascular disease, led by an international team led by the University of Washington School of Medicine and the University of California, San Francisco, San Francisco Dangers of Alzheimer's disease.

Scientists have long spore Genes involved in cholesterol and lipid metabolism, Alzheimer's disease. The gene is known to double the risk of Alzheimer's disease in some patients and increase the risk 12 times in other patients. However, in this new study, the researchers identified other DNA points that appear to be involved in both cardiovascular risk and the risk of Alzheimer's disease.

The findings were published in the Acta Neuropathologica journal on November 12.

"This discovery provides an opportunity to consider changing the use of drugs that target pathways involved in lipid metabolism," said Dr. Celeste M. Karch, associate professor of psychiatry at the University of Washington School of Medicine. "There are many things that need to know about how genes that increase the risk of Alzheimer's disease can increase the risk of other health problems." Some of these drugs armed with this study are useful for preventing or delaying Alzheimer's disease , Especially cardiovascular disease and vice versa, so we need to think more holistically about these dangers. "

This is the largest genetic study of Alzheimer's disease. Karch is one of the co-lead author with Rahul S. Desikan, MD, PhD, assistant professor of neuro radiation therapy at UC San Francisco. The first author of the study was Dr. Iris Broce-Diaz, a post-doctoral researcher at Desikan's laboratory.

The researchers observed DNA differences in people with heart disease or other factors that affect Alzheimer's disease and identified 90 points across the genome in relation to the risk of both diseases. According to their analysis, six out of 90 regions had a significant impact on Alzheimer's and blood lipid levels, including many of the genes not associated with dementia risk. Here, CELF1 / MTCH2 / SPI1 Chromosome 11, previously linked to the immune system.

The researchers identified the most promising results in large-scale genetic studies of healthy adults by showing that these risk factors are more common among people with a family history of Alzheimer's disease, despite the absence of other symptoms such as dementia or memory loss.

They focus on specific risk factors for heart disease, such as high body mass index, type 2 diabetes and triglycerides and cholesterol levels (HDL, LDL, total cholesterol), as are well known risk factors for heart disease and also for Alzheimer's risk and genetic .

"The genes that affect lipid metabolism are related to the risk of Alzheimer's disease," he said. Genes that contribute to BMI and other cardiovascular risk factors, such as type 2 diabetes, do not seem to contribute to the genetic risk of Alzheimer's disease. "

Desikan suggests that even more research is needed, but it may be possible to lower the risk of Alzheimer's disease by managing cholesterol and triglycerides if the right genes and proteins can be targeted.

"This result implies that genetically linked is meaningful regardless of the pathology of cardiovascular disease and Alzheimer's disease, so if you have this mutation, you are at risk for Alzheimer's disease as well as heart disease. "

Broce I, Karch C, Desikan R, et al. Analyzes the genetic relationship between cardiovascular risk factors and Alzheimer's disease. Acta Neuropathologica, published online November 9, 2018.

This study was supported by the National Institute of Aging, NIH-AG046374 and K01 AG049152, of the National Institute of Health (NIH). National Alzheimer 's Coordinating Center Junior Investigator Award, North American Residents' Radiology Society / Foundation plaque, US National Institute of Neuroscience Alzheimer' s Surveillance Committee, Norwegian Study Committee, Southeast Norwegian Health Authority, Norwegian Health Authority KG Jebsen Foundation.

1,500 faculty physicians at the University of Washington School of Medicine also work with Barnes-Jewish and St. Louis. Medical staff at Louis Children 's Hospital. The School of Medicine is a leader in US research and education, ranking first in the nation's top ten medical schools in the US News and World Report. Barnes-Jewish and St. It is linked to BJC HealthCare in partnership with Louis Children 's Hospital.

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