Without heart force people taking a daily aspirin can reduce their risk of a heart attack or stroke, but a new study confirms that they also have an increased risk of severe internal bleeding.
American doctors have long advised adults who have not had a reoccurrence or stroke, but are at high risk for these events to take a daily aspirin, known as primary prevention. Although there is clear evidence that aspirin works for this purpose, many doctors and patients are not enough to follow the recommendations due to the risk of rare but potentially fatal internal blood.
For the current study, researchers examined data from 13 clinical issues that control the effects of aspirin against placebo or no treatment in over 164,000 adults.
People who at the same time have aspirin names, reported 0.38 percent lower absolute risk of heart attacks, disorders or deaths from cardiovascular events than those who do not take these drugs, reported researchers in JAMA.
Aspirin, however, was also associated with a 0.47 percent higher absolute risk of severe internal bleeding.
"The results show that there are cardiovascular benefits, but that they are completely adjusted by increased risk of serious bleeding," said lead student writer Dr. Sean Zheng of King's College London and Imperial College London.
"This seriously questions whether people who have had or have not previously had heart attacks should take aspirin with the aim of lowering future cardiovascular events," Zheng said via e-mail.
Although some guidelines on primary heart rate prevention aspirin in the United States, Europe, and Australia have a need to control the potential benefits against blood risk. For older people, having a higher risk of blood than younger adults, the risk may be too large to drive aspirin.
For example, for adults 50 to 59 after aspirin to prevent heart attacks and sticks, the US Advantage Service Task Force (USPSTF) recommends only pills that have at least 10 percent risk of a heart attack or over next decade and no higher-than-average risk of blood.
People in the current study were at age 62 at & # 39; It was cut and traveled in age from 53 to 74. Half of them were followed for at least five years in the minor clinical problems that were used for current analysis.
Aspirin was not associated with a lower risk of beneficial deaths from all causes or events such as heart attacks and sticks found mainly in study.
The pills were associated with a 15 percent lower risk of heart attacks and a 19 percent lower chance of ischemic strokes, the most common type that occurs when a bell remains a bloodline in the resin.
One limitation of one's analysis is that the smaller clinical problems have investigated several aspirin doses from 50 to 500 milligrams, see the study vehicle's. Other doctors today dose higher than 100 mg.
Nevertheless, the results strive for the need for doctors and patients to have a smart discussion about the benefits and damage of aspirin for primary prevention of heart attacks and sticks, writes Dr. Michael Gaziano from Brigham and Women & # 39; s Hospital in Boston is a lead editor.
"Clients need to try other approaches to aspirin, such as tasting control and control of blood pressure and lipid levels, the lower risk" writes Gaziano.
"At places of no world where risk of cardiovascular disease is risking or there are preventative strategies, such as statins, less available, aspirin or a low intervention can play an important role," "Gaziano fell.
"Aspirin remains an important medication for the acute management of fascic events, for use with certain secondary prevention procedures" – that is, for preventing a second reinfection or stroke – and, after careful selection, from good paths, for primary prevention ".