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Scientists have found out why some people are immune to COVID-19



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Scientists have found out why some people are immune to COVID-19

Scientists have found out why some people are immune to COVID-19

American scientists described the main mechanisms of the formation of immunity against COVID-19 and answered the question why some people are not sensitive to a new … RIA Novosti, 01/29/2021

2021-01-28T22: 00

2021-01-28T22: 00

2021-01-29T00: 27

science

coronavirus (COVID-19

coronavirus

biology

Good health

United States

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MOSCOW, JANUARY 28 – RIA Novosti. U.S. scientists described the main mechanisms of immune formation against COVID-19 and answered the question why some people are not susceptible to a new coronavirus infection, despite the fact that they are not previously ill and have not been vaccinated. Published in the journal Science, the COVID-19 pandemic revealed a wide range of immune responses in humans infected with the SARS-CoV-2 coronavirus, and, consequently, a wide variety of clinical outcomes. Researchers at the Sanford Burnham Prebis Institute for Medical Discovery (SBP) in La Jolla, California, Jennifer Hope and Linda Bradley, describe the major mechanisms of immunity formation in COVID-19. By introducing host cells, viruses activate cellular mechanisms of self-replication, allowing them to spread further to the most sensitive cells. To fight the virus, the immune system encompasses innate immune responses, such as inflammation, which in turn activate the adaptive immune system. Dendritic cells store viral proteins and particles, transport them to the lymphoid organs, where they are presented to T and B cells. When these cells recognize the virus – as a rule, this happens when the virus enters the body. already arrived – the cellular (T-cell) and humoral (B-cell) branches of the adaptive immunity begin to work together, providing effective protection together. Both T-cell and B-cell responses play an important role in the control of viruses and the development of immunity. The vaccination strategy is based on this. At the same time, the researchers found that the T- and B-cell response to SARS-CoV-2 often occurs in people who have not encountered this virus before. Perhaps, the authors believe, the presence of such cellular immunity in these people is associated with the existence in their body, T and B cells, specifically for other human coronaviruses of the HCoVs family, which manifests itself in the form of a “cold”. T cells that respond to the SARS-CoV-2 egg proteins have also been identified in individuals previously infected with the SARS-CoV SARS virus. Similarly, IgG antibodies of COVID-19 patients react strongly to the egg white of coronaviruses with colds. Therefore, according to scientists, immune responses to SARS-CoV-2 depend to a large extent on the history of previous encounters with viruses of each individual. or previous infections with other respiratory infections other than immune-mediated conditions such as asthma increase or decrease susceptibility to SARS-CoV-2, and understand the underlying differences in adaptive immune responses between children and adults.

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coronavirus covid-19, coronaviruses, biology, health, usa

MOSCOW, JANUARY 28 – RIA Novosti. U.S. scientists described the main mechanisms of immune formation against COVID-19 and answered the question why some people are not susceptible to a new coronavirus infection, despite the fact that they are not previously ill and have not been vaccinated. The study is published in the journal Science.

The COVID-19 pandemic has revealed a wide range of immune responses in people infected with the SARS-CoV-2 coronavirus, and, consequently, a wide range of clinical outcomes.

Researchers at the Sanford Burnham Prebis Institute for Medical Discovery (SBP) in La Jolla, California, Jennifer Hope and Linda Bradley, have described the underlying mechanisms of immunity in COVID-19.

Penetrating into host cells, viruses trigger cellular mechanisms of self-replication, allowing them to spread further to the most sensitive cells. To fight the virus, the immune system triggers innate immune responses such as inflammation, which in turn activate the adaptive immune system.

Dendritic cells take up viral egg proteins and particles, transporting them to the lymphoid organs, where they present to T and B cells. When these cells recognize the virus – as a rule, this happens when the virus has already entered the body – the cellular (T-cell) and humoral (B-cell) branches of the adaptive immunity begin to work together, taking care of each other for effective protection. Both T-cell and B-cell responses play an important role in the control of viruses and the development of immunity.

Woman with a cold - RIA Novosti, 1920, 26/01/2021

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An adaptive branch of the immune system generates a protective immune memory. The vaccination strategy is based on this. At the same time, the researchers found that the T- and B-cell response to SARS-CoV-2 is more common in people who have not been exposed to this virus before.

Perhaps, the authors believe, the presence of such cellular immunity in these people is associated with the existence in their bodies of T and B cells specific for other human coronaviruses of the HCoVs family, which manifests itself in the form of a “common cold”. T cells that respond to the SARS-CoV-2 egg proteins have also been identified in individuals previously infected with the SARS-CoV SARS virus. Similarly, IgG antibodies of COVID-19 patients respond strongly to the egg proteins of common cold-related coronaviruses.

Therefore, according to scientists, immune responses to SARS-CoV-2 are largely dependent on the history of previous encounters with viruses of each individual person.

In the future, the authors plan to investigate whether previous infections with other respiratory infections or immune-mediated conditions, such as asthma, increase or decrease susceptibility to SARS-CoV-2, as well as to understand the differences in adaptive immune responses between children are and adults are based on.

The virus in the blood - RIA Novosti, 1920, 01/20/2021

Scientists have figured out how long-term immunity to COVID-19 is formed




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