People with the same quality of life do not always have the same quality of life. If we live longer, to extend the quality of life – "healthspan" – is great. Scientists in the Okinawa Institute of Science and Technology Graduate University (OIST) have found a gene that has been linked to "" healthy aging in the roundabout C. elegans, light on the genetics of healthcare.
The team identified a named elpc-2 C. elegans this plays an important role in the preservation of the health team as the worm. This gene is conserved in humans – and worms with defects in this gene have potent movement when they are old. Older movement is an indication of human speech and worm speech.
"When we age, some people have complete locomotive skills, while others do not, and we want to understand the genetic reasons," says Dr. Kazuto Kawamura, first author of the study, published in G3: the gene, genomes, genetics. "This gene is one of many playing a role in healthy aging."
"Our new experimental approach also allows us to examine hundreds of simultaneous simultaneous checks, which can be useful for other researchers."
C. elegans is a useful model for studying older people – it has a short time and can be easily manipulated into a laboratory. Kawamura placed random mutations in the genome of these worms. By researching & # 39; the poster of & # 39; e mutated forms, he could examine which mutations affected the health spectrum. He determined whether the organisms could move to move to a food source, as they were.
Worms were placed in the center of a dish with food at one edge. They look naturally at food, for not moving their movement. All worms that were unable to eat on the first day were judged to have moved a young age and were removed from the experiment – Kawamura was only interested in how they would return with this age.
The remaining mutants were again saved as they grow older with the same approach, doubling the "edge assay" to close the worms to the rim to get food. In this subsequent test, various worms were shown with proper movement.
These were subsequently sequenced and their DNA compared to a common "wild type" worm to identify the mutations and identify the responsible genes.
"Hundreds of random mutants are not that difficult," says Kawamura, "but it's hard to figure out which mutation is responsible for the locomotive skill impact."
In this way, the researchers identified elpc-2 and their role in health. The genetic code encodes part of the agonizing complex, which has many important functions, such as the orchestral circuits of the proper ovarian failure. Some of these proteins may, in new, have roles in locomotives.
Mutants with a damaged elpc-2 gene found a working elongate complex, which explains why movement was caused. To confirm this, Kawamura entered these worms with a working copy of & apos; s gene, and the movement was restored. He also made these a fluorescent copy expression from an elongate complex, illustrating his widespread expression through the body.
Other genes were probably identified as having a strong impact on health – but not lifelong. In other words, the underlying mutations have little effect on how long a worm lived, but had an impact on how they moved. This means that the health tension and the lifespan overlap, the genetic basis is different.
The elongate complex is only one part of the health game. Then follow Kawamura to research other genes that play a role in healthy aging.
"Once you have a full picture of your friends, we can start to improve health," says Kawamura. "First into C. elegans and maybe, one day, people. "