The maker of SpongeBob SquarePants is 57 years old.
Stephen Hillenburg was diagnosed with degenerative motor neuron disease (ALS) in March last year
In a statement Variance, directors of the Nickelodeon network in which the full love cartoons sounds say they are "unlucky hit by the news that Steve Hillenburg has left for a break with ALS".
"He was a friendly friend and long creative partner to everyone on Nickelodeon, and our heart goes to his whole family. SpongeBob SquarePants with a unique sense of humor and innocence, it has been enjoying generations of children and families everywhere. His early original drawings and the world of Bikini Bottom will be long as a reminder of the value of optimism, friendship and the incomprehensible power of fantasy. "
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An earlier marine biologist, Hillenburg used his artistic skills to make the characters that ultimately the Bikini Bottom providers become teachers. After deciding to look for an animation career, he became director and writer in mid-1990s Nickelodeon Rocko's Modern Life.
The first episode of his next project SpongeBob SquarePants debuted in May 1999. Since then, more than 250 episodes have been written with the show that is popular with both children and students.
The series won both American and British Emmy Awards and is known or subtitled in more than 60 languages, such as Urdu, Azerbaijani and Maori.
Hillenburg has also written, made and registered in 2004 The SpongeBob SquarePants Film and wrote and executed production of his 2015 The SpongeBob Movie: Sponge Out of Water.
He was survived by his wife of 20 years Karen Hillenburg, son Clay, mother Nancy Hillenburg (no Dufour) and brother Brian Kelly Hillenburg, his wife Isabel, and no Emma and Hazel.