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MicroRNAs that are close to the DNA involved in autism



MicroRNAs that are close to the DNA involved in autism

Source: Sciencesetavenir.fr

12/11/2018 10:03

Emory University and the Australian Academy of Sciences team studied the role of microRNAs in the development of autism spectrum disorders. Imagine a cure that works for your mouse.

The genetic causes of autism become more and more known. One study involves the malfunction of microRNAs called MIR-137 in the onset of this disease. What is microRNA? This is a small molecule close to DNA, but it is not a function that encodes a protein that makes cells. Micro-RNAs (also called miRNAs) play a role in regulating biological processes such as cell development, differentiation, growth and metabolism. It inhibits the expression of other genes by degrading the messenger RNA (which has the function of coding for the protein) or stopping the synthesis of the protein.

According to a number of studies published in recent years (especially the paper by Ebrahim Mahmoudi and Murray Cairns Natural Molecular Psychology 2017), MIR-137 plays an important role in brain function. In fact it controls hundreds of genes. Failure to do so can damage the activity of this gene, causing cell dysfunction that can lead to neuropsychiatric disorders, including autism. However, the exact mechanism of this phenomenon is not well known. What is lacking to fill the findings of Emory University and the Chinese Academy of Sciences research team Natural neuroscience …

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