After the research team inserted the encapsulated stem cells into a hydrogel made of silk fibroin, the cerebral stroke achieved the restoration of the function of the mice.
Alberto Iglesias Praga
Mexico City, November 10 (TICbeat / SinEmbargo). Imagine the following: Encapsulated stem cells In Harmless biomaterial It is totally biocompatible to achieve functional recovery of people with cerebral infarction, Neural tissue repair Damage can be avoided by extending the injury.
It sounds like science fiction, but it does not get farther away from reality. A team of researchers at the Biomedical Technology Center at the University of Madrid Polytechnic (UPM), in collaboration with the Complutense University of Madrid (UCM), the Cajal Institute and San Carlos Hospital, Rats with cerebral stroke after transplantation Encapsulated stem cells Hydrogel Silk fibroin.
Various neurological disorders cause permanent physical and cognitive impairment. Our nervous system has very limited ability to recover after injury, such as in stroke and brain damage, and on the other hand, as in neurodegenerative diseases Alzheimer's disease or Parkinson's disease Where the function of our brain deteriorates gradually. Stem cell therapy is a huge strategic leap forward in the treatment of these diseases given the therapeutic potential of protecting and treating damaged brain. However, stem cell transplantation is an important barrier to achieving the best therapeutic efficacy without the difficulty of reducing the survival rate in the brain after transplantation.
To overcome these obstacles, the Spanish scientists have developed new biotechnology strategies to repair damaged brain tissue. To this end, mesenchymal mice were used to transplant mesenchymal stem cells into silk fibroin, a harmless biocompatible biomaterial. After treatment, rats significantly improved their sensory and athletic abilities, which had significant changes after cerebral infarction. Using electrophysiological techniques, the researchers also demonstrated that this improvement was accompanied by a phenomenon of brain reorganization in the area adjacent to the damaged area. An important aspect of this study is that silk fibroin significantly increases the survival of transplanted stem cells in the brain, causing stroke in the animal and preventing further expansion of the damage.
Daniel Gonzalez Nieto, CTB UPM researcher, said: "This result opens up a promising path to neurological dysfunction through a new type of advanced therapy using silk fibroin as a means of drug delivery, Increase the improvement. "
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