"[김태열 기자의 생생건강] If a "tall, skinny woman" has a "BRCA bearer", the incidence of breast cancer will increase further. "- The Herald

– Breast cancer incidence rate of BRCA donor increased by 9% when height was 10cm ㆍ 6% by increase by BMI 5kg / m2
– World-wide attention was given to the world-renowned journal of the National Cancer Institute 'JNCI'
– In Korea, Dr. Seongwon Kim, Daelim St. Mary's Hospital and Korean Hereditary Breast Cancer Research (KOHBRA) participated.

[헤럴드경제=김태열 기자] A multinational team led by Dr. Seongwon Kim of the Daelim St Mary's Hospital and Korean Hereditary Breast Cancer Study (KOHBRA) has published a study on the relationship between breast cancer and key BMI and BRCA donors.

This study has been named as 'BRCA1 / 2 Mutation Carriers', the Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA Carriers and the Mendelian Randomization Approach We analyzed and analyzed genetic information of 14,676 BRCA1 donors and 7912 BRCA2 donors. Based on data from the international research group CIMBA (Consortium of Investigators of Modifiers of BRCA1 / 2), the study was published in the Journal of the National Cancer Institute (JNCI) I got big attention.

▷Larger 10 cm in height increased breast cancer incidence by 9% in BRCA carriersThe study found that the greater the height, the greater the risk of breast cancer in BRCA carriers. According to a study published by the Vanderbilt University research team, the same study was conducted on general women. As a result, it was found that the greater the height of 10 cm of general women, the higher the risk of breast cancer by 17%.

The study also found that the greater the height of a BRCA donor 10 cm, the greater the risk of developing breast cancer by 9%. Nutritional status and hormone status during childhood have a large impact on height, and these nutritional status and hormonal status are important links in the relationship between key and breast cancer occurrence.

The hormone-related insulin like growth factor signaling pathway has been found to be involved in the development of several cancers, including breast cancer. Recently, LIN28B-let-7 microRNA pathway, which is associated with adult height, body shape, metabolism, aging of blastocysts, and cancer, has been shown to play an important link between key and breast cancer development. The researchers hope that this study will contribute to more individualized prediction of the incidence of breast cancer in BRCA carriers.

▷ BRCA bearer, BMI 5 kg / m2 increases the risk of breast cancer by 6%= Not only the key but also the BMI (kg / ㎡). The risk of breast cancer was reduced by 6% every time the subject's BMI increased by 5 ㎏ / ㎡. The relationship between BMI and breast cancer incidence was found to be related to insulin-like growth factor-1 levels, anovulatory menstruation, and blood estrogen and progesterone levels.

However, in a study of women in general, it was found that the risk of breast cancer increases by 12% in postmenopausal women and by 8% in premenopausal women when the BMI increases by 5 kg / The risk of breast cancer in BRCA carriers may be related only to premenopausal women.

"The risk of breast cancer may vary from person to person, and this study has been conducted for a long time to predict individual risk of developing breast cancer," said Kim Sung-won, director of the Daerim St. Mary's Hospital. And genetic counseling that is age-appropriate using BMI is very significant. "

The Journal of the National Cancer Institute (NCI) is a journal published by the National Cancer Institute (NCI). It is one of the most influential media in the oncology field (cited 15.678). JNCI is published every other week and has been rated as a highly influential journal of cancer with a score of 15.171 in 2005 (SCI impact factor)

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