Taking fish oil or vitamin D? A large study presents a long-awaited answer to who will benefit from these popular nutrients.
Fish oils taken by healthy people found in many supplements have not shown a clear ability to lower the risk of heart or cancer. It is the same as vitamin D.
However, the more refined the prescribed amount of fish oil, the fewer heart problems and heart-related deaths in people at risk for hyperlipidemia, blood fat and heart disease. Doctors have shown cheers in the results and said they can offer new therapies to hundreds of thousands of patients like these.
10% of American adults consume fish oil. There are no major studies that support many health claims, but some people take vitamin D as well.
Dr. James Stein, a cardiologist at the University of Wisconsin-Madison, said, "People who are promoting good news for everyone." In this breakthrough test, Vitamin D said, "I did not show anything. I did not play any role in the relationship.
The results were revealed at the American Heart Association meeting in Chicago on Saturday and were published by the New England Journal of Medicine.
These oils, also known as omega-3 fatty acids, are found in salmon, tuna and other fish. Reducing triglycerides and inflammation can have different effects. There are several types, including EPA and DHA.
One study tested 4 g daily for more than 8,000 patients with hyperlipidemia and prescription Vascepa (intensive EPA) from Amarin Corp., which had a higher risk of heart disease for various reasons. I've already been taking statins such as Lipitor or Zocor to lower cholesterol levels. Half compared to Basefar and the rest are mineral oil capsules.
Five years later, about 17% of people in Basepa suffered from heart attack, stroke, heart-related death, or clogged arteries that required medical care.
Risk reduced by 25%. Individually, heart attacks, heart-related deaths, and strokes were all lowered to Basefar. Stein said, "Only 21 people were required to take Basefepa for five years to prevent friendly success, one of the major problems studied.
Side effects can be a concern. More people at Vascepa were hospitalized with irregular heartbeats, and 3% were hospitalized compared to 2% of the comparison group. Other studies say the doctor is embarrassed because fish oil suggests lowering the risk.
Concern about cardiac rhythm problems could increase the risk of stroke, but Deepak Bhatt, a researcher at Brigham and Women's Hospital in Boston, said that the number of stroke cases among Basse patients was low.
Vascepa costs $ 280 a month. Many insurance companies reward it. Amarin sponsored the research, and some research leaders worked or consulted at the company.
Other studies have tested the EPA / DHA combo sold as Lovaza or Omacor and a typical form of fish oil for heart disease or cancer in 26,000 people using 1 gram of fish oil per day.
About five years later, the combined measures of heart attack, stroke, and other problems were similar in fish oil users and in the comparison group. Cancer rates and mortality rates were similar.
Heart attacks in the fish oil group ranged from 145 to 200, which was lower in the comparison group. Research leader Brigham and Dr. JoAnn Manson of Women said it was "a pretty good thing," but several independent experts are studying this and other studies I have a disagreement.
"The results of this study are speculative and need to be confirmed in separate clinical trials," said Dr. Steven Nissen of Cleveland Clinic.
Both studies share the problem: the oil used in the comparison group may not be a true placebo. The Vascepa study used mineral oil that interfered with statin drugs to increase cholesterol levels, worsen the fares of comparative groups, and make Vascepa look better than it really is.
Other studies have used olive oil, which may have helped the comparison group prevent any benefit from being hidden from others in fish oil.
The leaders of both studies agree that the effect of the comparative oil is not enough to change the main outcome, and independent experts agree. However, Nissen, another fish oil research leader, uses corn oil for comparison.
Manson's study also tested vitamin D, which occurs when the skin is exposed to the sun. Many foods are now difficult to get enough food such as milk, eggs, and oily fish. Some studies show that people with low D levels have a high chance of getting cancer, but they do not know if the supplements are changing the risk.
Study participants consumed 2,000 units over five years for D-3 (the most active form of vitamin D, also known as cholecalciferol) or fake vitamin pills.
Vitamin D has not affected the risk of heart attack, stroke or onset. By excluding the first two years of use, researchers found that the number of deaths from cancer in the placebo group was reduced by 149 versus vitamin 112.
"Cancer can take years to develop," Manson says, so the difference may not be immediately apparent. "It looks promising," she said, "as long as the trend is maintained.
Some other experts said the figure suggests possible benefits that require more research.
"Clifford Rosen of the Maine Medical Center Research Institute at the University of Massachusetts, and John Keaney of the University of Massachusetts, Dr. Jr. wrote in a medical journal commentary.