A study linking debilitating cerebrovascular disease to Alzheimer's disease and vascular dementia has been published today in the Neuroscience Society, the Neuroscience 2018 Annual Meeting, and the latest news on brain science and health. Molecules that signal damage in this system can help early detection of these diseases and signal more effective interventions.
Alzheimer's and vascular dementia cause memory, cognitive and learning disabilities. Although there is an important genetic risk factor for this disease, there is strong evidence that vascular diseases such as hypertension and heart disease play an important role. The research published today demonstrates how the brain's vascular system is damaged and contributes to neurodegeneration, and a new mechanism for potential protective or therapeutic interventions such as exercise.
Today's new research results are as follows:
- Molecules called biomarkers that indicate cerebrovascular damage can allow intervention and treatment to identify dementia at early stages and to improve patient outcomes (Berislav Zlokovic, Abstract 469.10).
- Cardiovascular exercise appears to improve white blood flow and prevent vascular disorders in a mouse model of dementia (Lianne Trigiani, abstract 467.15).
- Depleted molecules in vascular dementia can be used for early detection or treatment of patients with this cognitive decline (Deron Herr, Abstract 469.27).
- Loss of age-related function in the brain's lymphatic system can play a role in neural degeneration and can help delay or prevent Alzheimer's disease (Jonathan Kipnis, abstract 267.02).
- The effect of blood-brain barrier is reduced in mice that have been engineered as the most potent genetic risk factor for Alzheimer's disease, resulting in neuronal loss and cognitive decline (Berislav Zlokovic, abstract 540.04).
Dr. Richard Wainford of the University of Boston School of Medicine said, "The findings published today increase understanding of two complex and related diseases." Knowledge of neurobiology and mechanisms can initially identify dementia It opens the door to new therapies and interventions that can help patients and their families around the world. "
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Related Neuroscience 2018 Presentation Lecture: Neural Order of Memory and Cognition Monday, November 5 3: 15-4: 25 p.m. SDCC Ballroom 20