New neuroimaging research reveals new insights into how tetrahydrocannabinol, or THC, the head psychoactive connection in cannabis affects humanity. The study found that THC increases glutamate concentrations in the striatum, an important corner structure that is involved in the coordination of body movement, decision making, and action initiation.
The new entries appear in a magazine European neuropsychopharmacy.
"Cannabis remains the most widely used illicit medicine in the world. However, the basic science of THC's commitment-effects are not yet fully understood," says study engineer Natasha L. Mason from the Neuropsychology department and Psychopharmacy at Maastricht University.
"In applying for an in-depth research design, a multimodal brain imaging strategy, the current study has sought to create a neurochemical context for THC-induced behavioral changes. We believe this information has a timely and broad application." beyond its scope in the field of psychopharmacology and neuroscience. "
"In light of changing legitimacy status and a growing interest in therapeutic benefit, it is important to understand the biochemical changes that prevent it from being used, and that may result from experienced therapeutic effects. In addition, 10% of the cannabis users are simultaneously developing patterns, the relevance of neuroadapters involved in this process is important for treating pollutants and realizing long-term potential consequences, "Mason explained.
The double-blind, placebo-controlled study of 20 healthy, occasional cannabis bone found THC introduction is associated with functional connectivity changes in the brain, which were connected to the right with lesser performance on attention-grabbing.
"There are two important findings from this study that are important in a broader sense. First, when people think of THC and cannabis, they think of dopamine as the main underlying mechanism of the (alluring) effects. Although not completely, our results say that glutamate in this also plays an important role, which is important not to understand how cannabis works in the brain, but also if you think about treatments for things like cannabis use of disorder, "said Mason PsyPost.
"Twenty, our results leave previous studies as demonstration that a certain level of THC (specific 2 ng / ml) should be present in blood to affect brain and cognitive function. As cannabis use becomes popular and access to medical cannabis is growing, these findings are important in common settings as well as imposing THC levels in blood levels. "
But there is still much to learn about how the THC influences the brain.
"In this study we have already tested cannabis tests, which we use every week for the week. Thus, the next step in this line of research is to design the same design in chronic (daily) cannabis users to use, "Mason said.
"This causes us to compare the changes of the brain between the two (ie all cannabis once use in & # 39; for people who smoke every day) and ultimately consider long neuroadaptions that can play a role in, for example, substantively, or can come from rectangular (therapeutic) use. "
The study, "Cannabis has a greater in striatal glutamate caused by loss of functional corticostatral connection", was written by Natasha L. Mason, Eef L. Theunissen, Nadia R.P.W. Huts, Desmond H.Y. Tse, Stefan W. Toennes, Peter Stiers, and Johannes G. Ramaekers.