Tuesday , January 31 2023

IPS stem cells transplanted into the brain of patients with Parkinson's disease


Japanese researchers have announced the implantation of so-called "iPS" stem cells into the brain of patients with Parkinson's disease.

The Kyoto University team injected 2.4 million of these. Pluripotent cells, Which can give all types of cells, on the left part brainIn the last 3 hours

Kyodo University said that the 50s are well guarded and monitored for two years.

If there are no problems in the next six months, the researcher will inject more than 2.4 million cells, and this time cells will be injected into the right side of the patient's brain.

It is believed that healthy donor iPS cells develop into neurons that produce dopamine, a neurotransmitter involved in motor control.

Kyoto University announced that it was holding this in July. Clinical trial It consists of 7 participants from 50 to 69 years old.

"I pay respect to patients with courageous and decisive participation."Professor Jun Takahashi quoted on Friday by the NHK public television channel commented.

Parkinson's disease The degeneration double Neuron Symptoms such as tremor, limb stiffness and decreased physical activity gradually worsen.

According to the Parkinson & apos; s Disease Foundation, it affects more than 10 million people worldwide. Currently available treatments & quot;Improve symptoms Without slowing down Progress of disease"Says the Foundation.

This new study is to reduce evil.

This test monkey According to a study published in Science Journal Nature at the end of August 2017, it relates to stem cells of human origin that can improve the athletic performance of primates suffering from Parkinson's disease. Survival of the transplanted cells by injection into the brain of the primate was observed for 2 years without the appearance of the tumor.

Derived pluripotent stem cells (IPS for derived pluripotent stem cells) is an adult cell that has returned to a near embryonic state (again inactive in adult cells) by expressing four genes again. this Genetic manipulation They reassure the ability to produce certain kinds of cells (pluripotent) depending on which part of the transplanted body.

The use of iPS cells does not cause fundamental ethical problems unlike stem cells from human embryos.

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