Tuesday , May 30 2023

Intestinal hormone ceccins activating brown adipose tissue


The intestinal hormone cecsin activates brown fat, which consumes a lot of energy.

The researchers found that the long-known intestinal hormone cicresin has a newly discovered additional function. It activates the brown adipose tissue that consumes energy and causes a satiety feeling.

Brown fat tissue helps in weight loss.

Because brown fat cells consume energy, experts say it can be a key to weight loss and is important in preventing obesity and diabetes. Only a few weeks ago, it turned out that brown fat tissue is as active as eating habits. The Munich University of Technology (TUM) and a team of colleagues from Finland have discovered the physiological mechanism of this activation.

New studies have shown that the intestinal hormone cicresin has a newly discovered additional function. It activates the brown fat consuming energy and induces satiety. New discoveries can help fight obesity. (Image: Kurhan / fotolia.com)

Long-Known Intestinal Hormones

"To our surprise, we have identified Cesectin as a key element." Professor Martin Klingenspor, a research leader at the Else Kröner-Fresenius Center for Nutrition Sciences (EKFZ) at TUM, said in a statement.

Secretin is a long-known intestinal hormone. Nutritional supplements have so far been presumed that this peptide as a messenger essentially performs gastrointestinal function.

As soon as the acidified chyme is released from the stomach into the small intestine, it stimulates the secretion of water and bicarbonate from the pancreas.

It also secretin as a brain messenger to facilitate secretin through the bloodstream. Even until recently, knowledge.

Satiety of the brain

The new study, published in the journal "Cell," has shown that transcriptome sequencing of genes for cercsin receptors is also expressed in brown adipose tissue.

"When we stimulate this receptor with cercreline in brown adipocytes, we can observe the immediate activation of heat generation without jitter," explains Klinginsport.

Crack-free heat generation is a typical mechanism for the formation of brown heat in heat, but it does not consume energy.

This study shows that shaker-free heat generation is also a prerequisite for a feeling of fullness in the brain.

The previously accepted lecture has been fixed.

As the message says, there are three possible channels from brown fat to the brain:

  1. Brain temperature rise,
  2. Neural connections from brown fat to the brain, or
  3. A special messenger of brown fat called so-called BATokine.

Professor Klingenspor regards heat forming itself as the most likely present at present.

"The heat generation of brown fat causes blood warming and brain temperature rise, which activates neurons that indicate saturation."

The hypothesis that a previously valid secretin acts directly on the brain in certain neurons to feel fullness and relieve hunger has been corrected by these results.

"Brown fat tissue is present like a relay station," says Klingensfor.

"An appetizer can fill you faster"

The communication chain between the newly discovered digestive tract and the brain begins with the release of secretin during feeding, resulting in the activation of brown lipid heat and brain warming, which increases satiety.

For example, heat generation induced by brown fat foods consumes energy and makes them rich. It is an important factor in preventing and preventing an obesity epidemic almost worldwide.

In this context, can secret agents be the right "medicine"? "No" makes Klingenspor clear. Chronic pancreatic irritation is not desirable.

But scientists have found a way to stimulate secretin production naturally through certain foods. "An appetizer can fill you up faster and reduce your calorie intake."

Nutrients to consider here are the topics of our future research. (Advertising)

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