Tuesday , November 30 2021

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The molecular engine Myosin 1D ensures asymmetry at all levels of movement of actin molecules (red and green filaments) to respiratory trachea (white-pink-like structures), to the organism itself (here is a Drosophila larva ). Credit: Picture of the larva: Gaëlle Lebreton; Photo editing by Stéphane Noselli / iBV / CNRS

Asymmetry plays a major role in biology on every scale: think of DNA spirals, the fact that the human heart is left, our preference is to use our left or right. A team from the Institute for Biology Valrose (CNRS / Inserm / Université Côte d'Azur), in collaboration with colleges of & nbsp; the University of Pennsylvania, has indicated how a few spell impresses a spatial motion in another molecule. Due to a domino effect, cells, organs, and thus the whole body cause it to cause, leading to lateral behavior. This research is published in the magazine Science on November 23, 2018.


Our world is asymmetrical: think of the double helix of DNA, the asymmetric division of stamens, or the fact that the human heart is on the left. But how are these asymmetries originated, and are they linked together?

At the Institute for Biology Valrose, a team led by CNRS researcher Stéphane Noselli, the researchers of Inserm and Universite Cote d'Azur, has researched into legal asymmetry several years to get these enigmas to get. The biologists have identified the first gene-contraction immune system in the Common Fruit Flea (Drosophila), one of the & # 39; The biologist favors model organisms. More recently, the team has shown that this genus plays the same role in the vertebrates: the protein that the product, Myosin 1D, controls the weapon or rotation of the same organ in the same direction.

In this new study, researchers have introduced the production of Myosin 1D into normal symmetric organs of Drosophila, such as the respiratory trachea. Spectacular was enough to stimulate asymmetry at all levels: deformed cells, trachea, tissue, divergence of the whole body, and helical location between flying larvae. Probably, these new asymmetres always develop in the same direction.

The movement of a normal larva (left) and a larva that expresses myosin 1D in its normal symmetrical epidermis. While the normal larvae just crows linearly, with its ventral side in contact with the fluid, the modified larva is twisted and moved by directional barrel rolls. Credit: Gaëlle Lebreton / iBV / CNRS

To identify the origin of these cascading effects, bio-techts of the University of Pennsylvania contributed to the project also: On a glass cover, Myosin 1D brought in contact with a cytoskeleton (the "background" of e cells), namely actin. They can observe that the interaction between the two protons causes the actin to spiral.

In addition to its role in right-left asymmetry under Drosophila and vertebrates, perhaps Myosin 1D is a unique being, the asymmetry in and of itself on all scales, first on the molecular level, by a domino effect on the cell, tissue, and behavioral level. These results show a possible mechanism for the sudden appearance of new morphological characteristics over the course of evolution, such as the slipping of snails & quot; bodies. Myosin 1D seems to have all the necessary characteristics for the emergence of this innovation, its expression has only enough to induce on all levels.


Expand further:
Atomy resolution of muscle contraction

More information:
"Molecular organismal chirality is promoted by the conserved myosin 1D" Science (2018). science.sciencemag.org/cgi/doi … 1126 / science.aat8642

Magazine reference:
Science

Provided by:
CNRS

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